Jayne Sutherland

Jayne Sutherland
Name:Jayne Sutherland PhD
Title:Immunologist
Email:jsutherland [at] mrc [dot] gm

Jayne completed her PhD in Immunology at Monash University (Melbourne, Australia) in 2002. Her thesis and subsequent 3 years post-doc in Melbourne and London involved cancer research, particularly immune system regeneration following chemotherapy and stem cell transplantation. She moved to MRC, The Gambia in 2006 and transferred her research interests to infectious diseases, primarily tuberculosis. She is in the TB immunology group headed by Dr. Martin Ota, under the Vaccinology theme headed by Dr. Beate Kampmann. She has extensive experience in multi-colour flow cytometry, multi-cytokine analysis by luminex, ELISA, cell culture and PCR. She has been involved in the Gates Grand Challenge 6: Biomarkers for TB project since 2007, which is a global consortium aimed at generating new diagnostics and vaccine candidates for TB. She is also involved in a continuation of this project, the AE-TBC project (African-European, TB Consortium), again looking at biomarkers for potential development of rapid TB diagnostics. Her other research interests include pleural TB diagnostics, TB/HIV interactions and antibody responses in TB.

key publications:
  1. Sutherland JS, de Jong BC, Jeffries DJ, Adetifa IM, Adegbola RA, Ota MO. Production of TNF-α, IL-12(p40) and IL-17 can discriminate between active TB disease and latent infection in a West African cohort. PLoS ONE. 2010 5:e12365.
  2. Young JM, Adetifa IM, Ota MO, Sutherland JS. Expanded polyfunctional T cell response to mycobacterial antigens in TB disease and contraction post-treatment. PLoS ONE. 2010; 5:e11237.
  3. Sutherland JS, Young JM, Peterson KL, Sanneh B, Whittle HC, Rowland-Jones SL, Adegbola RA, Jaye A, Ota MO. Polyfunctional CD4(+) and CD8(+) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment. J Immunol. 2010; 184:6537-6544
  4. Sutherland JS, Jeffries DJ, Donkor SA, Walther B, Hill PC, Adetifa IM, Adegbola RA, Ota MO. 2009; 89:398-404
  5. Sutherland JS, Adetifa IM, Hill PC, Adegbola RA, Ota MO. Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur J Immunol. 2009; 39:723-729