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Theme Leader Vaccines & Immunity
Professor of Paediatric Infection & Immunity 

Trained as a clinician-scientist in paediatric infectious diseases, Professor Kampmann was appointed as Theme Leader for Vaccines & Immunity research at the MRC Unit The Gambia at the LSHTM in July 2010. Having worked at Imperial College for over 20 years, where she held a professorship since 2011, she recently took up a position at the LSHTM as Professor in Paediatric Infection & Immunity and Director of The Vaccine Centre. The aim of Beate's research is to link scientific discoveries in the laboratory to the delivery of evidence-based care for children in the UK and Africa. In The Gambia, she directs multiple projects and clinical trials exploring maternal and infant immunisation as a tool to decrease infant morbidity and mortality. This extends from the associated questions of transplacental antibody transfer, impact on developing neonatal immunity, role of co-infections and co-morbidities to the challenges of acceptancy and implementation of vaccines.

Her vaccine-related work focuses on applying systems vaccinology tools to improve our insights into the development of the neonatal immune system, in the context of infections and vaccination and through the conduct of clinical studies and trials. She has also conducted translational research in childhood tuberculosis for many years with a focus on correlates of protection, biomarkers for disease progression and development and evaluation of novel diagnostics.

 

       Selected Key Publications

  1. Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, Williams B, Williams A, Liebeschutz S, Riddell A, Bernatoniene J, Patel S, Martinez N, McMaster P, Basu-Roy R, Welch SB. Evaluating UK National Guidance for Screening of Children for TB: A Prospective Multi-centre Study. Am J Respir Crit Care Med. 2017 Nov 30.
  2. Le Doare K, O'Driscoll M, Turner K, Seedat F, Russell NJ, Seale AC, Heath PT, Lawn JE, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Madhi SA, Rubens CE, Saha SK, Schrag S, Sobanjo-Ter Meulen A, Vekemans J, Kampmann B; GBS Intrapartum  Antibiotic Investigator Group. Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review. Clin Infect Dis. 2017 Nov 6;65(suppl_2):S143-S151
  3. Le Doare K, Faal A, Jaiteh M, Sarfo F, Taylor S, Warburton F, Humphries H, Birt J, Jarju S, Darboe S, Clarke E, Antonio M, Foster-Nyarko E, Heath PT, Gorringe A, Kampmann B. Association between functional antibody against Group B Streptococcus and maternal and infant colonization in a Gambian cohort. Vaccine. 2017 May 19;35(22):2970-2978
  4. Kollmann TR, Kampmann B, Mazmanian SK, Marchant A, Levy O. Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. Immunity. 2017 Mar 21;46(3):350-363.
  5. de Silva TI, Kampmann B. Value of immunogenicity studies of influenza vaccine in resource-limited settings. Lancet Glob Health. 2017 Mar;5(3):e274.
  6. Egere U, Togun T, Sillah A, Mendy F, Otu J, Hoelscher M, Heinrich N, Hill PC, Kampmann B. Identifying children with tuberculosis among household contacts in The Gambia. Int J Tuberc Lung Dis. 2017 Jan 1;21(1):46-52.
  7. Clarke E, Saidu Y, Adetifa JU, Adigweme I, Hydara MB, Bashorun AO, Moneke-Anyanwoke N, Umesi A, Roberts E, Cham PM, Okoye ME, Brown KE, Niedrig M, Chowdhury PR, Clemens R, Bandyopadhyay AS, Mueller J, Jeffries DJ, Kampmann B. Safety and immunogenicity of inactivated poliovirus vaccine when given with measles-rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia. Lancet Glob Health. 2016 Aug;4(8):e534-47
  8. Saso A, Kampmann B. Vaccination against respiratory syncytial virus in pregnancy: a suitable tool to combat global infant morbidity and mortality? Lancet Infect Dis. 2016 Aug;16(8):e153-63.
  9. Togun TO, Egere U, Gomez MP, Sillah AK, Daramy M, Tientcheu LD, S Sutherland J, Hill PC, Kampmann B. No added value of interferon-γ release to a prediction model for childhood tuberculosis. Eur Respir J. 2016 Jan;47(1):223-32
  10. Grassly NC, Kang G, Kampmann B. Biological challenges to effective vaccines in the developing world. Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671).
  11. Roca A, Afolabi MO, Saidu Y, Kampmann B. Ebola: a holistic approach is required to achieve effective management and control. J Allergy Clin Immunol. 2015 Apr;135(4):856-67

       Research Interests

  • Vaccines
  • Neonatal immunity
  • Maternal vaccination
  • Systems vaccinology
  • Childhood tuberculosis
  • T cell immunity
  • Biomarker discovery
  • Clinical Trials

       Projects

  • GaPs
  • HIPC
  • Reach4Kids Africa
  • Reach4Kids
  • IMPRINT network
  • MatImms Africa
  • Speaking Books