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Postdoctoral Research Fellow

Dr Eniyou Cheryll Oriero’s current research is on genomic epidemiology of non-falciparum malaria parasites. Very little is known about the dynamics of mixed Plasmodium infections and the impact of current interventions on these neglected parasite species. Knowledge of the transmission pattern of non-falciparum parasite species will support Elimination programmes to develop a wholistic approach to tackle potential complications that could arise as falciparum infections decline. Prior to this, Dr Oriero has a background in Biochemistry and Molecular Biology and began her research career after obtaining a Masters degree, working on tissue culture, genetic transformation and molecular characterization of food crops. Dr Oriero moved to medical research when she joined the Medical Research Council Unit The Gambia at LSHTM, in order to broaden her skills and knowledge in Molecular Biology applications. Since moving to medical research, she has worked on several malaria research projects and is motivated to continue generating knowledge on natural dynamics of malaria infections in Africa.

 

       Selected Key Publications

  1. Roca A, Okomo U, Usuf E, Oriero EC, Janha R, Achan J, Cerami C; MRC Unit The Gambia Women in Science Working Group. African women working in global health: closing the gender gap in Africa? Lancet Glob Health. 2018 Apr;6(4):e369
  2. Eniyou C. Oriero, Joseph Okebe, Jan Jacobs et al. Diagnostic performance of a novel loop mediated isothermal amplification (LAMP) assay targeting the apicoplast genome for malaria diagnosis in a field setting in sub-Saharan Africa. Malaria Journal 2015, 14:396 doi: 10.1186/s12936-015-0926-6.
  3. Oriero C Eniyou, Van geertruyden Jean-Pierre, Jacobs Jan et al. Validation of an apicoplast genome target for the detection of Plasmodium species using polymerase chain reaction (PCR) and loop mediated isothermal amplification (LAMP). Clin Microbiol Infect 2015; 21: 686.e1–686.e7
  4. Oriero C Eniyou, Van Geertruyden Jean-Pierre, Nwakanma Davis, D’Alessandro Umberto, Jacobs Jan.  Novel techniques and future directions in molecular diagnosis of malaria in resource-limited settings. Expert Rev Mol Diagn. 2015 Sep 28:1-8.
  5. Oriero EC, Jacobs J, Van Geertruyden JP et al. Molecular-based isothermal tests for field diagnosis of malaria and their potential contribution to malaria elimination. J. Anitimicrob. Chem. 2015 70(1): 2-13.
  6. Caputo B, Nwakanma D, Caputo FP, Jawara M, Oriero EC, Hamid-Adiamoh M, Dia I, Konate L, Petrarca V, Pinto J, Conway DJ, Della Torre A. Prominent intraspecific genetic divergence within Anopheles gambiae sibling species triggered by habitat discontinuities across a riverine landscape. Mol Ecol. 2014 Sep;23(18):4574-89
  7. Nwakanma DC, Duffy CW, Amambua-Ngwa A, Oriero EC, Bojang KA, Pinder M, Drakeley CJ, Sutherland CJ, Milligan PJ, Macinnis B, Kwiatkowski DP, Clark TG, Greenwood BM, Conway DJ. Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection. J Infect Dis. 2014 Apr 1;209(7):1126-35
  8. van der Hoek W, Sarge-Njie R, Herremans T, Chisnall T, Okebe J, Oriero E, Versteeg B, Goossens B, van der Sande M, Kampmann B, Nwakanma D.Short communication: prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa. Trop Med Int Health. 2013 Jul;18(7):850-3
  9. Huang H, Mackeen MM, Cook M, Oriero E, Locke E, Thézénas ML, Kessler BM, Nwakanma D, Casals-Pascual C. Proteomic identification of host and parasite biomarkers in saliva from patients with uncomplicated Plasmodium falciparum malaria. Malar J. 2012 May 28;11:178.
  10. Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA Jr, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, et al. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar;121(3):175-83

       Research Interests

  • Population Genomics
  • Genomic Epidemiology
  • Molecular Epidemiology
  • Bioinformatics
  • Molecular Diagnostics

       Projects