MRCG at LSHTM Team Receive Grand Challenges Exploration Award

Dr. Thushan de Silva, Dr. Abdul Karim Sesay, Helen Brotherton, and Prof. Beate Kampmann of the Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine have received a Grand Challenges Exploration Award to develop a novel metagenomic approach to detect infectious pathogens in hospitalised preterm neonates in The Gambia. […]

Pneumococcal Vaccine Schedules Study Begins

​The Pneumococcal Vaccine Schedules (PVS) study, is a 4 year collaborative study between MRCG at LSHTM and the Ministry of Health (MoH) The study aims to evaluate an alternative schedule for Pneumococcal Conjugate Vaccine (PCV) compared to the current schedule. All resident infants (birth cohort ~10,000) in the Basse (URR) and Fuladu West (CRR) Demographic […]

Long-distance transmission patterns modelled from SNP barcodes of Plasmodium falciparum infections in The Gambia

Malaria has declined significantly in The Gambia and determining transmission dynamics of Plasmodium falciparum can help targeting control interventions towards elimination. This can be inferred from genetic similarity between parasite isolates from different sites and timepoints. Here, we imposed a P. falciparum life cycle time on a genetic distance likelihood model to determine transmission paths […]

Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction

BACKGROUND: Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010-2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016. […]

Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines

BACKGROUND: Aetiological data for neonatal infections are essential to inform policies and programme strategies, but such data are scarce from sub-Saharan Africa. We therefore completed a systematic review and meta-analysis of available data from the African continent since 1980, with a focus on regional differences in aetiology and antimicrobial resistance (AMR) in the past decade […]

Infections that cause malaria in humans spread long distance by human migration across The Gambia

Malaria has declined significantly in The Gambia and determining transmission dynamics of Plasmodium falciparum may help better targeting control interventions towards its elimination, according to research published in Scientific Reports. Malaria remains a significant health problem across most of Africa, despite gains made in reducing burden across most countries. To sustain these gains and accelerate […]

Wide Equity Gaps Persist in Many West African Countries Despite Progress in Increasing access and utilization of Immunisation Services for Children

Despite the introduction of an increasing number of vaccines to the Expanded Programme on Immunisation (EPI), and huge government and development partners’ investments, many children globally continue to go unvaccinated by their first birthday or never complete the recommended schedule. In sub-Saharan Africa, particularly in West Africa, vaccination coverage rates are lower than in other […]

Largest systematic review of neonatal infection aetiology and AMR from sub-Saharan Africa reveals need for better reporting and improved surveillance

Hospital-acquired neonatal infections and AMR are a major burden in sub-Saharan Africa, and improved surveillance is required, according to a new review of 151 studies comprising data from 84534 neonates from 26 countries, published in The Lancet Infectious Diseases. Serious bacterial infections in newborn babies – sepsis, meningitis, and pneumonia – are a leading cause […]

Genomics of S. aureus following oral intrapartum azithromycin

Globally, more than 2.5 million neonatal deaths occur every year, and a third of these deaths are caused by severe bacterial diseases, which often present as sepsis. In sub-Saharan Africa, neonatal sepsis is caused primarily by Gram-positive bacteria with Staphylococcus aureus often associated with these infections. Oral azithromycin (AZI) prophylaxis has been shown to be […]

WANETAM 2 Entomology Training in Burkina Faso: Vector Bionomics and Innovative Vector control strategies for Malaria Elimination

The malaria node of The West African Network of Excellence for TB, AIDS and Malaria (WANETAM-2) organized the second entomology training workshop, for 30 participants, in Bobo-Dioulasso, Burkina Faso from 19th to 31st August 2019. The workshop was hosted in collaboration with the Centre d’Excellence Africain en Innovations Biotechnologiques pour l’Élimination des Maladies à Transmission […]

Drug Discovery Offers New Hope To Halt The Spread Of Malaria

Breakthrough research has revealed a new drug that may prevent the spread of malaria, and also treat people suffering with the deadly parasitic disease. The findings, which were delivered by an international team of scientists led by the University of Glasgow, including Omar Janha and Dr. Davis Nwakanma from the MRC Unit The Gambia at […]