MRC Unit Funded Projects (Core Programme 2006-11)
- Phenotypes and molecular mechanisms of erythrocyte invasion by Plasmodium falciparum in severe and mild malaria
- Analysis of the role of P. falciparum virulence genes in severe malaria by candidate gene and whole transcriptome analysis of short-term ex vivo cultured parasites
- Testing for virulence polymorphisms in P. falciparum by candidate gene and whole genome allelic association analysis of a severe malaria case-control study
- Studying the potential role of regulatory T cells in conferring immunity to severe malaria
- The role of T cell apoptosis and haem oxygenase in severe malaria
- Determinants of naturally acquired antibody isotype responses against malaria antigens and their duration and protective efficacy
- The effect of persistent parasitaemia on immune responses and risk of malaria
- New methodologies for diagnostic malaria parasitology
