Alfred Amambua-Ngwa has been awarded a $3.1 million grant by AESA for the Pan African Malaria Genetic Epidemiology Network

5 October 2018

Dr Alfred Amambua-Ngwa is a Senior Scientist and Head of Malaria Population Biology Group in the Disease Control and Elimination Programme of MRCG at LSHTM. Dr Amambua-Ngwa obtained a PhD in Biochemistry from the Biotechnology Unit at the University of Buea, Cameroon in 2004 with a thesis research focus on identifying and characterizing Onchocerca volvulus proteins associated with pathogenicity and immunity in filaria. He immediately joined the University of Buea teaching core as an Assistant Lecturer of biochemistry and molecular biology. He received four training awards from the International Programme in the Chemical Sciences (IPICs), developing skills in molecular genetics, recombinant DNA technology, reverse genetics, protein crystallography and bioinformatics at the Universities of Salford (UK), Nottingham (UK) and Lund (Sweden). He established recombinant DNA technology and reverse genetics at the University of Buea, directing the laboratory training of several master’s and PhD students.

Dr Alfred Amambua-Ngwa Senior Scientist and Head of Malaria Population Biology Group

In 2006, he moved to MRCG at LSHTM to focus on malaria cell biology and population genetics with over 50 publications to his credit. He was the first African scientist to hold the prestigious MRC Career Development Award and is co-Principal investigator in several research and capacity building programmes in cell biology, genomics and bioinformatics of infectious pathogens. He is a member of the African societies of Biochemistry, Antimicrobial resistance and Human Genetics.

For thousands of years, humans have been adapting to resist malaria parasites. In turn, malaria parasites evolve to evade our immune system and antimalarial drugs. Understanding this deadly evolutionary struggle is crucial to maintain the efficacy of antimalarial drugs, discovering new treatments, and developing effective vaccines.

The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a team of African scientists studying how genetic changes in humans and malaria parasites impact on the disease in individuals and communities in different ecological environments.

In order to infect humans, malaria parasites need to invade our red blood cells by exploring cell surface receptors such as the glycophorins. PAMGEN will focus on studying genetic variation in parasite ligands, human red blood cell glycophorin receptors and variations in the outcome of malaria. The network will assess temporal and spatial variation in malaria intensity across seven sub-Saharan African countries (The Gambia, Ghana, Mali, Cameroon, Kenya, Ethiopia and Madagascar). The data will allow for analysis of genomic interactions between the three genomes involved in malaria – human, parasite, and mosquito.

In line with the rules of the H3Africa consortium, PAMGEN will focus on generating high quality data and samples that will be shared within the network and the wider scientific community. Ultimately, the network will explore data from human, parasite and vector populations in designing functional genomics research that will drive the development of new tools to support malaria elimination programmes across Africa.