Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines

BACKGROUND: Aetiological data for neonatal infections are essential to inform policies and programme strategies, but such data are scarce from sub-Saharan Africa. We therefore completed a systematic review and meta-analysis of available data from the African continent since 1980, with a focus on regional differences in aetiology and antimicrobial resistance (AMR) in the past decade […]

Infections that cause malaria in humans spread long distance by human migration across The Gambia

Malaria has declined significantly in The Gambia and determining transmission dynamics of Plasmodium falciparum may help better targeting control interventions towards its elimination, according to research published in Scientific Reports. Malaria remains a significant health problem across most of Africa, despite gains made in reducing burden across most countries. To sustain these gains and accelerate […]

Wide Equity Gaps Persist in Many West African Countries Despite Progress in Increasing access and utilization of Immunisation Services for Children

Despite the introduction of an increasing number of vaccines to the Expanded Programme on Immunisation (EPI), and huge government and development partners’ investments, many children globally continue to go unvaccinated by their first birthday or never complete the recommended schedule. In sub-Saharan Africa, particularly in West Africa, vaccination coverage rates are lower than in other […]

Largest systematic review of neonatal infection aetiology and AMR from sub-Saharan Africa reveals need for better reporting and improved surveillance

Hospital-acquired neonatal infections and AMR are a major burden in sub-Saharan Africa, and improved surveillance is required, according to a new review of 151 studies comprising data from 84534 neonates from 26 countries, published in The Lancet Infectious Diseases. Serious bacterial infections in newborn babies – sepsis, meningitis, and pneumonia – are a leading cause […]

Genomics of S. aureus following oral intrapartum azithromycin

Globally, more than 2.5 million neonatal deaths occur every year, and a third of these deaths are caused by severe bacterial diseases, which often present as sepsis. In sub-Saharan Africa, neonatal sepsis is caused primarily by Gram-positive bacteria with Staphylococcus aureus often associated with these infections. Oral azithromycin (AZI) prophylaxis has been shown to be […]

WANETAM 2 Entomology Training in Burkina Faso: Vector Bionomics and Innovative Vector control strategies for Malaria Elimination

The malaria node of The West African Network of Excellence for TB, AIDS and Malaria (WANETAM-2) organized the second entomology training workshop, for 30 participants, in Bobo-Dioulasso, Burkina Faso from 19th to 31st August 2019. The workshop was hosted in collaboration with the Centre d’Excellence Africain en Innovations Biotechnologiques pour l’Élimination des Maladies à Transmission […]

Drug Discovery Offers New Hope To Halt The Spread Of Malaria

Breakthrough research has revealed a new drug that may prevent the spread of malaria, and also treat people suffering with the deadly parasitic disease. The findings, which were delivered by an international team of scientists led by the University of Glasgow, including Omar Janha and Dr. Davis Nwakanma from the MRC Unit The Gambia at […]

Ancestral clans of malaria parasites in each region of Africa share drug resistance genes, putting malaria elimination at risk

Whole genome sequence analysis of malaria parasites and other pathogens could pave the way for improved understanding of infections and development of new intervention approaches for elimination. In the first continent-wide genomic study of malaria parasites in Africa, a team of African scientists, in collaboration with the Wellcome Sanger Institute have uncovered distinct regional populations […]

Antimalarial resistance surveillance and mechanisms in African malaria parasites

Malaria continues to be one of the most important public health problems in Africa. Children and pregnant women are disproportionately affected. There are recent fears that the disease is resurging, despite the increased deployment of insecticide and antimalarial drugs. The malaria parasites in some regions of the world such as South East Asia have developed […]

Maternal, Neonatal & Child Health – Promoting synergies to address pressing maternal and neonatal health across our three themes

Annually, pregnancy hypertension, fetal growth restriction (FGR), and stillbirth unrelated to intrapartum events are associated with 46,000 maternal and 2.5 million fetal, neonatal and infant deaths. Over 99% of these deaths occur in low and middle-income countries (LMICs), and over half in sub-Saharan Africa. The PRECISE consortium was established in 2018 to address this area […]

Our Genomics Core Facility: A Bold Step For The Unit

The establishment of a Genomics Core Facility at our Fajara site represents a bold undertaking for the Unit, and aligns with our agenda to build a strong core genomics capability, and become a stronger partner in the emerging “southern” genomics alliances, particularly in West Africa. The Unit has already secured and will be investing on […]