Population genomics of Plasmodium malariae in Southern Nigeria

The Gambia Hepatitis Intervention Study (GHIS)

Mass drug administration of ivermectin and dihydroartemisinin-piperaquine as an additional intervention for malaria elimination (MASSIV)
Contact: Umberto d'Alessandro
Funded by: Medical Research Council

Will the ongoing use of a two-dose, rather than three-dose schedule of pneumococcal conjugate vaccine, have similar impact in rural Gambia? (PVS - JGHT)
Contact: Grant McKenzie
Funded by: Medical Research Council

The Rotavirus vaccine effectiveness study (VIDA)
Contact: Jahangir Hosain
Funded by: Bill and Melinda Gates Foundation

Can improved housing provide additional protection against clinical malaria over current best practice? A household-randomised controlled trial
Contact: Margaret Pinder
Funded by: Medical Research Council

Randomised controlled trial of early kangaroo mother care for hospitalised neonates <2000g (eKMC- Helen Brotherton's Fellowship)
Contact: Helen Brotherton
Funded by: Wellcome Trust

Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)
Contact: Efua Yussuf
Funded by: European Union

Maximising the public health impact of interventions to control malaria in pregnancy through the translation of EDCTP-funded evidence-based global policies to country level policies and plans (IMPPACT)
Contact: Umberto d'Alessandro
Funded by: European Developing Countries Clinical Trial Patnership

The relationship between malarial anaemia, neutrophil function and susceptibility to invasive bacterial disease (AMAN)
Contact: Umberto d'Alessandro
Funded by: Medical Research Council

A Phase 2 interventional, multicenter, randomized open-label study to determine the effective and tolerable dose of KAF156 and Lumefantrine Solid Dispersion Formulation in combination, given once daily for 1, 2 and 3-days to adults and children with uncomplicated Plasmodium falciparum malaria (CKAF)
Contact: Umberto D'Alessandro
Funded by: IQVIA (Formerly Quintiles)

Reactive household self-administered treatment against residual malaria tranmission (RHOST)
Contact: Umberto D'Alessandro
Funded by: Medical Research Council

Pre-delivery administration of azithromycin to prevent neonatal sepsis and death: a phase III double-blind randomized (Pregnanzi II)
Contact: Anna Roca
Funded by: Medical Research Council

Rheumatic Heart Disease
Contact: Annette Erhart
Funded by: Wellcome Trust

Feasibility of the Nanobubble Technology for Detection of Malaria (Malarisense 2)
Contact: Umberto D'Alessandro
Funded by: Masimo Corp

Research towards infectious disease elimination on the Bijagós Archipelago of Guinea Bissau (West Africa)
Contact: Umberto d'Alessandro

The mechanisms underlying the production of natural mosquito repellents by human beings
Contact: Umberto d'Alessandro

West African Network for TB AIDS and Malaria (WANETAM 2)
Contact: Umberto d'Alessandro

African coaLition for Epidemic Research, Response and Training (ALERT)
Contact: Umberto d'Alessandro

Developing excellence in leadership, training and science (DELTAS) ‘Malaria Research Capacity Development in West and Central Africa’
Contact: Umberto d'Alessandro

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)
Contact: Umberto d'Alessandro

Using medical-detection dogs to identify people with malaria parasites
Contact: Umberto d'Alessandro

A cluster-randomized non-inferiority trial of the effect of a two compared to three dose schedule of pneumococcal conjugate vaccine (PVS-BMGF)
Contact: Grant McKenzie
Funded by: Bill and Melinda Gates Foundation

Population based approach to malaria research and control (ICEMR)
Contact: Davis Nwakanma
Funded by: National Institutes of Health

Gambia Hepatis Intervention Study (IARC)
Contact: Ramou Njai
Funded by: World Health Organisation

Surveillance of invasive Haemophilus influenzae type b (Hib) infection in the Western Region of The Gambia
Contact: Akram Zaman
Funded by: Gavi, the Vaccine Alliance

Monitoring insecticide resistance in The Gambia
Contact: Umberto D'Alessandro
Funded by: Global Fund

Developing excellence in leadership, training and science (DELTAS) Africa Award: ‘WACCBIP-WELLCOME TRUST DELTAS PROGRAMME’
Contact: Alfred Ngwa
Funded by: Wellcome Trust

Real time malaria surveillance data capture using Mobile data collection service (MDCS)
Contact: Umberto D'Alessandro
Funded by: Global Fund

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)
Contact: Umberto D'Alessandro
Funded by: European Union

Developing Excellence in Leadership and Genetic Training for Malaria Elimination in Sub-Saharan Africa (DELGEME DELTAS- Mali)
Contact: Alfred Ngwa
Funded by: Wellcome Trust

Towards the end game: operational research on improving rural housing in sub-Saharan Africa as a strategy to support malaria elimination
Contact: Margaret Pinder
Funded by: Durham University

MalariSense 2016
Contact: Umberto d'Alessandro
Funded by: National Institues of Health

Malaria Research Capacity Development in West and Central Africa (MARCAD DELTAS Senegal)
Contact: Umberto d'Alessandro
Funded by: Wellcome Trust

The PROLIFICA screen and treat intervention programme in The Gambia, West Africa: a second phase of liver assessment
Contact: Maud Lemoine
Funded by: Gilead

Evaluation of 10-13 Valent pnuemococcal conjugate vaccine in The Gambia: A Phase IV effectiveness Study (PSP)
Contact: Grant McKenzie
Funded by: Bill and Melinda Gates Foundation

PSP 2017- A study to determine the impact of PCV13 on pneumocoocal carriage and to prepare for a trial of alternative PCV scheduling in The Gambia
Contact: Grant McKenzie
Funded by: Bill and Melinda Gates Foundation

PSP 2017- Extension of a study to measure the full impact of PCV13 on invasive pneumococcal disease and radiologic pneumonia in The Gambia
Contact: Grant McKenzie
Funded by: Pfizer

Plasmodium falciparum drug resistance in The Gambia: identification of potential markers by retrospective genomics approaches (CDA Award)
Contact: Alfred Ngwa
Funded by: Medical Research Council

Genetic interactions between human populations and malaria parasites in different environmental settings across Africa
Contact: Alfred Ngwa
Funded by: Alliance for Accelerating Excellence in Science in Africa

 

 

A Study of Intranasal Live Attenuated Influenza Vaccine Immunogenicity and Associations with the Nasopharyngeal Microbiome Among Children in the Gambia (NASIMMUNE) 
Contact: Dr Thushan deSilva; Prof Beate Kampmann
Funding: Wellcome Trust

Exploring mucosal molecular signatures associated with successful challenge with live attenuated influenza viruses
Contact: Dr Thushan deSilva
Funding: Human Infection Challenge Vaccine Network

Assessing Group Streptococcal Pyoderma in The Gambia (SPYDERM)
Contact: Dr Thushan deSilva
Funding: Higher Education Funding Council for England

Site-preparedness and acceptancy of vaccines to be given in pregnancy- a WAGHA project
Contact: Prof Beate Kampmann; Dr Elhadji Mbaye (IRESSEF); Penda Johm, PhD student MRC
Funding: Imperial College/Pfizer

EPIC-HIPC: Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity
Contact: Prof Beate Kampmann, Dr O Idoko, Dr A Darboe
Funding: National Institutes of Health

Making every baby count: a facility-based audit and review of stillbirths and neonatal deaths in The Gambia
Contact: Dr. Uduak Okomo
Funding: Wellcome Trust-ISSF scheme

Maternal IgG and Neonatal Innate Immune Cells
Contact: Dr. Alansana Darboe
Funding: MRC UK-funded IMPRINT Network Fellowship

Periscope: Developing improved vaccines against pertussis
Contact: Prof Beate Kampmann, Dr Mike Okoye
Funding: European Union/Innovative Medicines Initiative /Bill & Melinda Gates Foundation

Audio-visual tool to train Primary Health workers to strengthen the Expanded Program on Immunization program in The Gambia
Contact: Prof Beate Kampmann
Funding: Bull City Learning

GAIA Extension : Global Alignment of Immunization safety assessment in pregnancy
Contact: Dr Ed Clarke
Funding: Brighton Collaboration Foundation

TB Biomarker study
Contacts: Prof Beate Kampmann, Dr Saikou Bah, Dr Toyin Togun
Funding: National institutes of Health

Reach4Kids: Improving diagnosis and management of childhood tuberculosis in the Gambia
Contacts: Prof Beate Kampmann, Dr Uzoh Egere
Funding: Medical Research Council Programme Grant

Reach4Kids Africa: Improving diagnosis and management of childhood tuberculosis in Africa
Contacts: Prof Beate Kampmann
Funding: Medical Research Council Global Challenge Research Fund - Foundation award

Improving the Diagnostics of Childhood Tuberculosis in High Burden Settings
Contact: Prof Beate Kampmann
Funding: Grand Challenge Canada

A randomized, observer-blind, non-inferiority trial to evaluate alternative human papillomavirus (HPV) vaccination schedules in females in West Africa
Contact: Dr Ed Clarke
Funding: Medical Research Council/ Welcome Trust/ DFID Global Health Clinical Trials Scheme

Maternal Immunization with MenAfriVac®
Contact: Dr Ed Clarke and Prof Beate Kampmann
Funding: Meningitis Research Foundation (MRF)

The microbiome, antibiotics and vaccine immunogenicity
Contact: Dr Ed Clarke
Funding: Stanford University

A pragmatic trial to quantitatively and qualitatively assess different techniques for the administration of fractional dose of inactivated polio vaccine (IPV)
Contact: Dr Ed Clarke and Dr Adedapo Bashorun
Funding: World Health Oganisaton

A randomized, controlled, double-blind, phase 3 trial to evaluate the effects of maternal or neonatal pneumococcal conjugate vaccination on pneumococcal
Contact: Dr Ed Clarke, Prof B Kampmann
Funding: Medical Research Council/ Welcome Trust/ DFID Global Health Clinical Trials Scheme

TB Sequel: Research networks for health innovation in sub-Saharan Africa
Contacts: Prof Beate Kampmann and Dr Jayne Sutherland
Funding: German Ministry for Research and Education (BMBF)

Screen-TB
Contacts: Dr Jayne Sutherland
Funding: European and Developing Countries Clinical Trial Partnership

TBVAC2020
Contacts: Dr Jayne Sutherland
Funding: European and Developing Countries Clinical Trial Partnership

GC6-2013: Biomarkers for TB consortium
Contacts: Dr Jayne Sutherland
Funding: Bill and Melinda Gates Foundation

A phase 3, randomized, double-blind study to evaluate the safety, tolerability, lot-to-lot consistency, immunogenicity, and non-interference with concomitant vaccinations
Contact: Dr Ed Clarke
Funding:  PATH Vaccine Solutions

VAC058 - A Phase I trial to assess the safety and immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP heterologous prime-boost vaccination co-administered with EPI vaccines in Gambian infants – in collaboration with the Malaria Vectored Vaccines Consortium 2 (MVVC2), the Jenner Institute in Oxford, UK and the Université Cheikh Anta Diop de Dakar (UCAD), Senegal

CSDILI
Contact: Thushan de Silva
Funded by: Vaccines and Immunity Theme (MRC Unit The Gambia at LSHTM)

Exploring the relationship between nutrition and vaccine responses
Contact: Olubukola Temitope Idoko
Funded by: Welcome Trust ISSF (Institutional Strategy Support Fund)

Seroepidemiology study of Zika virus and other arboviral fevers in selected West African countries
Contact: Olubukola Temitope Idoko
Funded by: University of Siena

Genes-in-Action: Hepcidin, iron and anaemia (5QX00)ING Core Science
Contacts: Carla Cerami, Momodou Wuri Jallow, Andrew Prentice
Funding: Nutrition Theme

BRIGHT (BRain Imaging in Global HealTh) - Developing brain function-for-age curves using novel biomarkers of neurocognitive development from birth in Gambian and UK infants'. 5QX0K0
Contacts: Clare Elwell, Sophie Moore, Sarah Lloyd-Fox or Sam McCann
Funding: Bill & Melinda Gates Foundation

MILQ (The Mothers, Infants, and Lactation Quality Project) 5QX0Q0
Contact: Sophie Moore
Funding: United State Department of Agriculture – Research, Education, and Economics (USDA)

ENID (Early Nutrition and Immune Development) 5QX00 – ING Core Science
Contacts: Sophie Moore, Momodou Darboe or Andrew Prentice
Funding: MRC ING core, with supplementary funds from the Bill & Melinda Gates Foundation

Impact of maternal diet on the epigenome and potentially modifiable effects on offspring health – MDEG 2 5QX0F0
Contacts: Matt Silver, Phil James or Andrew Prentice
Funding: MRC

EMPHASIS (Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia) – 5QX0J0
Contacts: Ayden Saffari or Matt Silver
Funding: Newton Fund (MRC, Indian DBT & UK DFiD)

Collaborative network for adolescent nutrition and health in sub-Saharan Africa and India -5QX0R0
Contacts: Landing Jarjou, Ramatoulie Janha , Sophie Moore
Funding: MRC GCRF

Creating a West African BioResource for Nutritional Genetics and Epigenetics
Contacts: Prof Andrew Prentice, Dr Carla Cerami, Dr Matt Silver,
Funding: MRC

Neonatal iron metabolism and risk of infection
Contacts: Carla Cerami, Andrew Prentice
Funding: Bill & Melinda Gates Foundation

Evaluation of MTHFR C677T genotype-dependent blood pressure response to riboflavin supplementation
Contacts: Modou Jobe, Andrew Prentice
Funding: The African Partnership for Chronic Disease Research (APCDR)

A novel nano-iron supplement (IHAT) to safely combat iron deficiency and anemia (IDA) - 5QX0L0
Contact: Dora Pereira, Andrew Prentice
Funding: Bill & Melinda Gates Foundation

Pregnancy Interventions In Mothers Relating to Diabetes In Asian India and Low-income countries (The PRIMORDIAL Study)
Contacts: Modou Jobe, Mustapha Bittaye, Andrew Prentice
Funding: MRC

Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia
Contacts: Matt Silver, Andrew Prentice
Funding: Bill & Melinda Gates Foundation

Pump Priming: Establishment of the Sub-Saharan African MuSculOskeletal Network
Contacts: Landing Jarjou, Kate Ward
Funding: GCRF, The Academy of Medical Sciences

Infection, inflammation and hepcidin-mediated iron deficiency anaemia in African children
Contacts: Carla Cerami, Andrew Prentice
Funding: MRC

Inter-generational risk factors for obesity: a path to prevention in low and middle-income countries based on a modifiable epigenetic signature in the POMC gene
Funder: MRC ING Core
Contacts: Matt Silver, Toby Candler, Andrew Prentice

Coast to Coast Transcontinental Ethics Partnership
Contact: Jonas Lexow
Funded by EDCTP