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Associate Professor of Immunology and Head of TB Research Group

Dr. Jayne Sutherland is the Head of the TB Research Group, consisting of the TB case-contact (TBCC) study cohort and the TB Immunology laboratory. Her PhD and early post-doctoral career in Australia and London focussed on cancer immunotherapy. She took up a post-doctoral position at MRCG in 2006 on biomarker discovery for TB. The TBCC platform provides a unique opportunity for multi-disciplinary research on TB and is run in close collaboration with the national TB program to promote health systems strengthening and public engagement. The TB Immunology research laboratory provides mechanistic insight and biomarker discovery underpinning all our clinical TB studies. This includes understanding host-pathogen interactions for development of host-directed therapies for TB; defining the role of non-classical T cells, B cells and antibodies in the early response to Mtb infection; defining correlates of risk for progression to active TB; immunity at the site of infection; immune responses to M. africanum (a prevalent strain in West Africa) compared to M. tuberculosis; and immunity to TB in the context of HIV and other co-infections.

       Selected Key Publications

  1. Suliman S*, Thompson E*, Sutherland J et al. Four-gene pan-African blood signature predicts progression to tuberculosis. AJRCCM. 2018. [Epub ahead of print]
  2. Coulter F, Parrish A, Declan Manning D, Kampmann B, Mendy J, Garand M, Lewinsohn DL, Riley EM, Sutherland JS. IL-17 production from Th17, MAIT and γδ cells in tuberculosis infection and disease. Front Immunol. 2017; 8: 1252
  3. Chegou NN, Sutherland JS, Malherbe S, Crampin AC, Corstjens PL, Geluk A, Mayanja-Kizza H, Loxton AG, van der Spuy G, Stanley K, Kotzé LA, van der Vyver M, Rosenkrands I, Kidd M, van Helden PD, Dockrell HM, Ottenhoff TH, Kaufmann SH, Walzl G; AE-TBC consortium. Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB. Thorax. 2016; 71: 785-794
  4. Elliott TO, Owolabi O, Donkor S, Kampmann B, Hill PC, Ottenhoff TH, Haks MC, Kaufmann SH, Maertzdorf J, Sutherland JS. Dysregulation of Apoptosis Is a Risk Factor for Tuberculosis Disease Progression. J Infect Dis. 2015; 212: 1469-1479
  5. Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S. M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. Cell Host Microbe. 2015; 18: 538-548
  6. Ota MOC, Mendy JF, Donkor S, Togun T, Daramy M, Gomez MP, Chegou NN, Sillah AK, Owolabi O, Kampmann B, Walzl G, Sutherland JS. Rapid diagnosis of tuberculosis using ex vivohost biomarkers in sputum. Eur. Respir. J. 2014; 44: 254-257.
  7. Sutherland JS,Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, Walzl G, Kaufmann SH, Ottenhoff TH; GCGH Biomarkers for TB consortium. Differential gene expression of activating Fcγ receptor classifies active TB regardless of HIV status or ethnicity. Clin Microbiol Infect. 2014; 20: O230-8
  8. Wilson H, de Jong BC, Peterson K, Jaye A, Kampmann B, Ota MOC, Sutherland JS. Skewing of the CD4+ T cell pool towards mono-functional antigen-specific responses in patients with immune reconstitution inflammatory syndrome in The Gambia. Clin Infect Dis. 2013; 57: 594-603.
  9. Sutherland JS, Young JM, Peterson KL, Sanneh B, Whittle HC, Rowland-Jones SL, Adegbola RA, Jaye A, Ota MO. Polyfunctional CD4+ and CD8+ T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment. J Immunol. 2010; 184: 6537-6544.
  10. Sutherland JS, Young JM, Peterson KL, Sanneh B, Whittle HC, Rowland-Jones SL, Adegbola RA, Jaye A, Ota MO. Polyfunctional CD4+ and CD8+ T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment. J Immunol. 2010; 184: 6537-6544.

       Research Interests

  • Biomarker discovery across the Mycobacterium tuberculosis (Mtb) infection spectrum
  • Flow cytometry for identification of antigen-specific cell populations involved in protective immunity to TB
  • The influence of co-infections (such as Influenza) on Mtb-specific immunity
  • Development of rapid point-of-care diagnostics
  • Identification of novel therapeutic strategies

       Projects